The Cancer Guru

The story behind B69
Here is a very basic definition of what is cancer

My cancer prevention and treatment is called B69 .  The B69 tablets have evolved as a result of  my trainings which is described on this page.

 

 My Ph.D research (in USA) on x-ray single crystal  structures of organotin (IV) Oxy and thio phosphorus acid derivatives of tin.  Crystal and molecular structure of triphenyltin(IV) phosphates compounds: Structure activities relationships. Mentor: J.J.Zuckerman.
and Dr.M.Bigwood (center-right).Picture by F.A.K.Nasser taken during one of our ACS meetings.
 Worth mentioning here is Dr.Earle Whipple (pictured below far left) is the son of Fred Lawrence Whipple: FLW (1906-2004)  Six comets named after him, Professor Fred L.Whipple is known for Comets composition.


 These novel compounds I synthesized show biological activities, anti-cancer:Proapoptotic (More than thirty novel drugs). Testing our hypothesis of bringing two toxic entities to form new bond with less toxicity to human cell. These findings are published in many peer-reviewed American Journals.See sample papers below.
M.S in basic medicine science from Wayne State University. School of Medicine.

Working on PUFA and endocanabinoids with mentor E.P.Schoener:
 

 Professor of Pharmacology, Director and the founder of Wayne state university Drug abuse

institute who is the student of Shih-Chun Wang: Columbia University, world-renowned scientist Pfeiffer professor of pharmacology and discoverer of the vomiting center in the CNS leading to discovery of anti-emetics drugs which is known for Borison-Wang model of emesis


Borrison and Wang are discoverers of the concept of “chemoreceptor trigger zone(CZT)” for emesis.

Wang, S. C.; Borison, Herbert L. (1951). Copper Sulphate Emesis: A Study of Afferent Pathways from the Gastrointestinal Tract. Am J Physiol - Legacy Content. 164 (2): 520-526.

Here is  a brief description of important individuals in my science journey ( see my genealogy on other page). If you have any question or comment  click here .


Vomiting may hold the key cause of death from Radiation

Japan Fukushima 2011


Dr. Herbert Leon Borison (1922-1990), an authority on brainstem neurophysiologySamples of Faik A Nasser postgraduate research: All the compounds I synthesized are proapoptotic.

http://pubs.acs.org/action/doSearch?action=search&author=F.+A.K.+Nasser&qsSearchArea=author

1.   Chemistry - To all it concerns

Faik A. K. Nasser

Journal of Chemical Education 1985 62 (2), 178

2.   Oxy and thio phosphorus acid derivatives of tin. 9. Di- and triorganotin(IV) diphenyl phosphate esters

K. C. Molloy, F. A. K. Nasser, J. J. Zuckerman

Inorganic Chemistry 1982 21 (5), 1711-1714

3.   Oxy and thio phosphorus acid derivatives of tin. 14. X-ray crystal and molecular structure of the dimeric bis[bis(O,O'-diphenylthiophosphato)diphenyltin(IV) hydroxide], [HOSnPh2OP(S)(OPh)2]2, at 138 K

F. A. K. Nasser, M. B. Hossain, D. Van der Helm, J. J. Zuckerman

Inorganic Chemistry 1983 22 (21), 3107-3111

4.   Crystal and molecular structure of bis[2-(aminocarbonyl)anilinium] dimethyltetrachlorostannate(IV) dihydrate at 138 K: a hydrogen-bonded network lattice

F. A. K. Nasser, M. B. Hossain, D. Van der Helm, J. J. Zuckerman

Inorganic Chemistry 1984 23 (5), 606-609

5.   Adsorption of carbonyl sulfide on nickel and tungsten films

Jalal M. Saleh, Faik A. K. Nasser

The Journal of Physical Chemistry 1985 89 (15), 3392-3394

6.   Organogermanium(IV), -tin(IV) and -lead(IV) esters of tetramethylenedithiocarbamic acid. The crystal and molecular structure of (tetramethylenedithiocarbamato)triphenyltin(IV) and lead(IV)

E. M. Holt, F. A. K. Nasser, A. Wilson, J. J. Zuckerman

Organometallics 1985 4 (12), 2073-2080

7.   Oxy and thio phosphorus acid derivatives of tin. 10. Crystal and molecular structure of triphenyltin(IV) diphenyl phosphate, a cyclic hexamer

K. C. Molloy, F. A. K. Nasser, C. L. Barnes, D. Van der Helm, J. J. Zuckerman

Inorganic Chemistry 1982 21 (3), 960-964

  Faik has Patents for hair restoration, beverages and know-how.M.S Candidate in Nutrition, Food science (Wayne State University). Discovery of methods prevent fruits and vegetables from browning. Toxicological studies in the field of neurology at University of Michigan, Ann Arbor work delivered and presented in international Toxicological conferences.

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=19079747

  Attended and/or delivered speeches about novel drugs structures and proteins in England, Germany, Canada and America.

        Here are the brief descriptions of the scientists who are connected to my work directly and indirectly through many mentors most of them Nobel Prize laureate.  J.J.Zuckerman:(1936-1987) Great organmetallic chemist, founding editor of the famous set of 19 volumes:

Inorganic reactions and methods. Organic chemistry of group IV elements.

       

          Faik A Nasser published several papers with J.J.Zuckerman.

The University of Oklahoma recently celebrated the 30-year anniversary of a collaborative exchange program between the Department of Chemistry and Biochemistry in the College of Arts and Sciences and the Technical University of Berlin. The exchange program, which began in 1976, was the result of collaboration between then OU chemistry department chair,Jerold J. Zuckerman (JJZ), and TUB chemistry professor Herbert Schumann.

                                                                n         
                                          Professor Herbert Schumann (1935-2010):

Schumann, along with Professors Ekkehardt Hahn (University of Münster) and Christoph Janiak (University of Freiburg), two of the program’s first German students who studied at OU in the early 1980’s, friends of Faik A. Nasser and co-workers at JJZ lab. Returned to the OU campus in September for the 30-year celebration. Professors Schumann, Janiak and Hahn presented public lectures through the Department of Chemistry and Biochemistry’s J. Clarence Karcher Distinguished Lecture series. Schumann also was presented with a plaque in honor of his leadership in establishing the exchange program.


In a letter dated Sept. 22, 1976, from OU President Paul F. Sharp to TUB President Alexander Wittkowsky, Sharp wrote, “It would be my pleasure to work with you in establishing an international collaborative effort between our two institutions. I am enthusiastically in favor of this proposal and will give it my fullest support.”

              Lev.D.Landau(1908-1968) is V.G.Litovchenko’s mentor. Vladimir Litovchenko* 
              Institute of Semiconductor Physics NASU, 45 prospect Nauki, Kiev 03028, Ukraine

My colleague V.Litovchenko with his wife Olga and their son early 1980s during my graduate research at the Univ. Of Oklahoma...good old days talking about superconductivity and drinking hot tea.  
  
                             V.G.Litovchenko is Fai   k’s colleague  (1981-1983) .     

  landau

 

 Lev Landau worked under N.Bohr

 The Man They Wouldn't Let Die By Alexander Dorozynski. 207 pp. The Macmillan Co., 60 Fifth Ave, New York 10011, 1965 James F. Holloran, Reviewer Boston.

Nobel Prize 1962 superconductivity, neutrino, superfluidity. Mentor of V.G.Litovchenko (Vladimir was close friend and coworker of Faik A Nasser).

N.BohrNiels Bohr and Albert Einstein debating quantum theory at Paul Ehrenfest's home in Leiden (December 1925). Nobel Prize in 1922 structure of atom. His student W.HeisenbergNiels Bohr close friend of Albert Einstein (Bohr and Einstein debate); A.N.Bohr son of N.Bohr received Nobel Prize too. J.J.

                                    

 D.Van Der Helm Faik’s mentor in crystall0-1983

 


http://pubs.acs.org/action/doSearch?action=search&author=F.+A.K.+Nasser&qsSearchArea=author

http://cat.inist.fr/?aModele=afficheN&cpsidt=9391196

Great crystallographer solve structures of biological active compounds solubilize iron called Siderophores, anticancer compounds from marines. Faik published with him. Those years he was in the forefront of those who applied the new power of computers to crystallography and moved the technique from the then common projection approach to the

3-dimensional methods. His pride, although he feels it only partially earned, was that in those days Patterson told lecture audiences that Dick had shown him, with his work, the real power of the vector synthesis (Patterson) method.A.L.Patterson and W.H.Bragg shared Nobel Prize 1915 with his son W.L.Bragg:Using studies on X-ray spectra, spectrometer, and diffraction (WHB and WLB) ALP found methods used in solving crystal structures of chemical compounds. J.J.Thomson and E.Rutherford  are mentors of  N.Bohr the latter influenced W.Pauli, W.Heisenberg, P.A.M. Dirac and Max Delbrück

J.J.Thomson: Nobel Prize 1906 discovered electron, isotopes and invented mass spectrometer. Some of his students received Nobel Prize include: W.H. Bragg, C.T.R.Wilson(NP 1927 cloud chamber) and E.Rutherford (NP: 1908, Father of nuclear physics) orbital theory of atom

 

Hermann Emil Fischer: Nobel Prize 1902.

 H.E.Fischer is the mentor of Otto Heinrich Warburg who is known for the prime cause and prevention of cancer.



 

(1852-1919)Discoverer of structures of main ingredient: caffeine in tea and coffee.

Synthesis of Sugars, purines: Glucose, fructose, and mannose in 1890, protein synthesis, Proline, and peptides. Faik discovered the unique role of proline in honey mentioned in his book” keys to healings”. Faik fascination with the role of N-CH3 in the drugs and  the drug of abuse can be seen through these molecules. Fischer  works  motivated O.H.Warburg to hypothesize the metabolic origin of cancer. The latter influenced Faik A.K.Nasser to hypothesize his theory on treating and prevention cancers ( Unpublished work).


Otto Heinrich Warburg

O.H.Warburg has shown, among other things, that cancerous cells can live and develop, even in the absence of oxygen

 Complexes of Silicon. Boron and boron hydrates use in rocket fuel

Alfred Stock (July 16 1876  August 12 1946) was a Germaninorganic chemist. He did pioneering research on the hydrides of boron and silicon, coordination chemistry, mercury, and mercury poisoning. The German Chemical Society's Alfred-Stock Memorial Prize is named after him. He worked as assistant to H.E.Fischer for 9 years.

 

                                     Alan G. MacDiarmid (1927-2007):Polyaniline
Nobel laureate 2000, conducting polymers
, I publish with his colleague J.G.Masters

  This paper is dedicated to thememory of my mentor professor J.J.Zuckerman

Journal of Organometallic Chemistry:Volume 385, Issue 1, 13 March 1990, Pages 39-48 Oxy- and thio-phosphorus acid derivatives of tin (IV). The crystal and molecular structure of O-methylmethylphosphatotriphenyltin(IV)*1 :J. G. Masters1, F. A. K. Nasser, M. B. Hossain, A. P. Hagen, D. van der Helm and J. J. Zuckerman

                        

 

 

H.J.Emeleus (1903-1993) Great British chemist one of  J.J.Zuckerman's mentors

 Is Arsenic an Aphrodisiac? The Sociochemistry of an Element, By William Cullen, H.J.Emeleus’s student

 

        

 A.Korenberg: Nobel Prize 1959 for DNA synthesis.

 The structure of eukaryotic RNA polymerase II (Science cover)

                                          
                                                            
F.Hirata: discovered Lipocortin (annexin A1)
potential use in treatment of rheumatoid arthritis without the side effects of glucocorticoids. Faik A Nasser worked in Hirata lab.

                                                                                    Fusao Hirata, MD, PhD

                                                                           Principal Investigator Bio:
Interferon. He moved to National Institute of Health, Bethesda, where his research was focused on modification of signal transduction by steroids. He is co-discoverer of annexin I as a second messenger of anti-inflammatory action of steroids. In the Johns Hopkins University, Baltimore, he discovered that annexin I is phosphorylated by oncogenic inases in signal transduction of growth factors. In Wayne State University, he recently found that nuclear annexin I, a biomarker of cell transformation, is a helicase with high affinity for damaged DNA. The study funded by the Suzan G. Komen Foundation is designed to search chemopreventive agents of breast cancer that block DNA damage induced mutation via annexin I. Computer biology will be used to design chemopreventive agents with greater efficacy and low toxicity for breast cancer, and designed agents will be tested by annexin I helicase and cell transformation assays. Dr. Hirata’s expertise in the field of annexin I is documented in over 60 publications. Fusao Hirata received his M.D from Tokyo Medical and Dental University, Japan, and obtained Ph.D. in Biochemistry at Kyoto University.

O.Hayaishi: Mentor of F.Hirata: The latter was mentor of Faik A Nasser at WSU 1991-1993

 


 

Father of sleep-wake cycle regulation, prostaglandin D2, Discovered oxygenases enzymes: Dioxygenase and monooxygenase. Example Cytochrome P450 oxidases

A Profile of Osamu Hayaishi

 An exciting new era in the study of biological oxidations emerged from works reported in 1955 by Howard S. Mason and his colleagues on mushroom phenolase and by Osamu Hayaishi and his coworkers on pseudomonad pyrocatechase. These investigators utilized the heavy oxygen isotope 18O to examine metabolic transformations and showed that oxygen atoms from molecular oxygen (O2) can be incorporated into organic substrates.This was a surprising finding because until that time O2 was only thought to serve as a terminal electron acceptor in biological oxidations. Enzymes catalyzing oxygen insertion reactions became referred to as oxygenases. There are monooxygenases and dioxygenases that incorporate either one or two atoms of molecular oxygen, respectively.While first discovered in lower organisms, oxygenases were soon found in various mammalian tissues by Dr. Hayaishi and many other investigators. Oxygenases are now known to be involved in the metabolism of sugars, amino acids, steroids, fatty acids and aromatic drugs and carcinogens. The molecular and catalytic properties of oxygenases have been thoroughly investigated with special reference to their prosthetic iron and copper and their flavin and pterin cofactors. Dr. Hayaishi and his colleagues have made major contributions to our understanding of oxygenases, especially those functioning in the metabolism of tryptophan, lysine and histidine and in the biosynthesis of bioactive eicosanoids. Most recently, Dr. Hayaishi has focused his studies on elucidating the role of prostaglandins in sleep.Dr. Hayaishi is well-known not only as a distinguished researcher but also as a stimulating and influential educator. More than 100 university professors and institute directors have received training in his laboratory. His famous "lunch seminar" served as an occasion for teaching his students how to read and discuss scientific articles critically and how to develop research projects so as make significant contributions to biology and medicine. His student F.Hirata continued this tradition at Pharmaceutical sciences department, Wayne state university where Faik A Nasser gave several seminars and later received degree

 in basic medical sciences on 2001. School of Medicine, Wayne State University.Dr. Hayaishi has contributed importantly to the IUBMB. He has given two plenary lectures at IUB and IUBMB Congresses, one in New York in 1964 and another in New Delhi in 1994. He was elected to the IUB Council in 1969, and served as the President of the IUB from 1973-1976. His autobiographical "Memoirs of a Biochemist" appeared in IUBMB Life, 58, 242-245 (2006).The Osamu Hayaishi Lecture was inaugurated in 1982 at the 12th IUB Congress in Perth, Australia and is sponsored by funds provided by Suntory Limited.

 J. Axelrode

  

Julius "Julie" Axelrod won the Nobel Prize in 1970 for neurotransmitter research conducted in part with the spectrophotofluorometer (SPF). Dr. Axelrod was born in 1912 in New York City and attended the College of the City of New York. After graduation he worked as a lab assistant and a research chemist. He then moved on to Goldwater Memorial Hospital, where he worked as Dr. Brodie's lab technician for many years. In 1949 both Axelrod and Brodie joined the newly formed National Heart Institute (NHI) and while at NHI Axelrod earned his doctoral degree at George Washington University.

In 1955, after completing his doctoral work, Dr. Axelrod became chief of the Section on Pharmacology at the Laboratory of Clinical Science at the National Institute of Mental Health (NIMH) and began using the new SPF in his research on neurotransmitters. With the SPF, he was able to measure tiny amounts of neurotransmitters in the brain. He studied norepinephrine and described the process for storage, release, and "re-uptake" by the cells as needed. For this work, he was awarded the 1970 Nobel Prize in Physiology or Medicine.

In 1970 Julie shared the Nobel Prize in physiology or medicine with Ulf von Euler and Sir Bernard Katz “for their discoveries concerning the humoral transmitters in the nerve terminals and the mechanism for their storage, release and inactivation

 

F.Hirata worked post doctorate in Axelrod lab. Faik A Nasser worked in F.Hirata laboratory on isolation of cytokines secreted by human monocytes. These interleukins and TNFs are secreted as a response to the LPS and Faik’s compounds made at Oklahoma Chemistry laboratories.

 

 J.Axelrod discovered neurotransmitters; epinephrine, norepinephrine, dopamine and Pineal gland hormones.

 Bernard Brodie and Julius Axelrod  demonstrated that acetanilide and phenacetin are both metabolized to paracetamol, which is a better tolerated analgesic.

Acetaminophen, Paracetamol, Panadol, Tylenol

                                      

  Bernard B. Brodie (1909-1989)

 

Dr. Bernard B. "Steve" Brodie was an internationally renowned pharmacologist whose groundbreaking work at Goldwater and NIH-including his involvement in the development of Tylenol-earned him many honors. Dr. Brodie attended McGill University in Montreal and then studied organic chemistry at New York University. He came to Goldwater Memorial Hospital to work with Dr. James Shannon's antimalarial group during World War II. His important publications in the 1940s helped lay the groundwork for the future study of drug metabolism.

As head of the Laboratory for Clinical Pharmacology at NIH after the war, Dr. Brodie worked with and trained a group of scientists who would become the leaders in the science of drug metabolism. Their work was accompanied by increased research into instrumentation and technology, including the spectrophotofluorometer. Dr. Brodie won the Lasker Award, often considered the American Nobel Prize, in 1967. The award cited his "extraordinary contributions to biochemical pharmacology."

N.F.Hall and J.B.Conant discovered super acids the work used by G.A.Olah to discover carbocations. G.A.Olah received Nobel Prize 1994.Olah introduced Methanol economy as replacement for hydrogen, ethanol and fossil fuel.

  

Linus C. Pauling injects the love of the nature of the chemical bond in Faik’s mindI fall in love in the structure of simple molecules and macromolecules .

 Double Nobel Prize winner the father of the nature of chemical bond, alternative medicine, alpha helix and beta-strand in protein structure.

Great advocate of Vitamin C. personal meeting with Faik A Nasser

 

 

LINUS CARL PAULING (1901–1994) Faik had scientific personal meeting with L.Pauling in Germany 1983.
Linus Pauling was the only winner of two unshared Nobel Prizes in different categories. He is also considered by many to be the greatest chemist of the 20th century. He was awarded the 1954 Nobel Prize in Chemistry for his work on molecular structure and chemical bonds, and he won the Peace Prize in 1962 for his efforts to prevent the testing and use of nuclear weapons.

Pauling came to Caltech as a graduate student, receiving his PhD in physical chemistry in 1925. He then joined the faculty, becoming a full professor in 1931 (at the age of 30), and chair of the chemistry and chemical engineering division six years later. In addition to his research on chemical bonding, he made important discoveries in molecular biology, such as identifying the genetic defect in the hemoglobin molecule that causes sickle-cell disease. In 1951, Pauling and Robert Corey discovered the alpha helix structure that serves as a universal structural building block for protein molecules. In the 1970s, Pauling provoked controversy by suggesting that large doses of Vitamin C would promote good health. After leaving Caltech in 1963, he was a member of the Center for the Study of Democratic Institutions in Santa Barbara, a professor at Stanford University, and director of research at the Linus Pauling Institute of Science and Medicine in Palo Alto.

 
 

Kenichi Fukui  1918-1998 Nobel Prize winner on theory of organic chemistry. Fukui had a personal meeting with Faik A Nasser

Kenichi Fukui


The Nobel Prize in Chemistry 1981

Nobel Lecture

  Nobel Lecture, December 8, 1981

The Role of Frontier Orbitals in Chemical Reactions

 

 

  

  Dorothy C. Hodgkin and F.A.K.Nasser ( meeting in Canada.)



 Hodgkin was a British chemist who pioneered 3 dimensional x-ray crystallography of molecules. She used this technique to discover the structure of many important biochemicals such as penicillin, vitamin B12 and insulin. For this work, she was awarded the 1964 Nobel Prize in Chemistry. She had Personal meeting with Faik A Nasser.

Prof. Herbert C. Brown(1912-2004)


 

 Nobel Prize winner in discovering new chemistry of HydroCarboBoranes.

Look at coincidence of his name initials and his work (H.C.B) Personal meeting with Faik A Nasser. In Germany in 1983 pictured above. Picture is personal collection of F.A.K.Nasser.

 

 

                

Here is the book where I  demonstrated the entourage concept in formulating cocktail of key extracts in a capsule 

 
My work with
Professor R.J.Richardson at the University of Michigan, Ann Arbor in the area of Toxicology and Bioinformatics :

Nasser, F.A., Wijeyesakere, S.J., Stuckey, J.A., and Richardson, R.J. (2006). Modeling the cyclic nucleotide binding domains of neuropathy target esterase (NTE). Society of Toxicology,

Annual Meeting, San Diego, CA, March 5 – 9, 2006.

Wijeyesakere, S.J., Nasser, F.A., Stuckey, J.A., and Richardson, R.J. (2006). Modeling the patatin domain of neuropathy target esterase. Fifth Annual Great Lakes Bioinformatics Retreat,

Grand Rapids, MI, July 31-August 1, 2006.

   · Nasser, F.A., Kampf, J.W., Wijeyesakere, S.J., Stuckey, J.A., and Richardson, R.J.       

Fluorinated aminophosphonates inhibit serine hydrolases via C-P bond cleavage. XVIIIth

Mendeleev Congress on General and Applied Chemistry, Moscow Russia, 23–28 September 2007.   

 

Acta Cryst. (2008). E64, o1425

 R. J. Richardson

 


Diethyl [2,2,2-trifluoro-1-phenylsulfonylamino-1-(trifluoromethyl)ethyl]phosphonate

S. J. Wijeyesakere, F. A. NasserJ. W. KampfA. Y. AksinenkoV. B. SokolovV. V. MalyginG. F.Makhaeva and  R. J. Richardson

CommentThe title compound is a member of the fluorinated a-aminophosphonate (FAP) group of compounds [(RO)2P(O)C(CF3)2NHS(O)2C6H5;= CH3, C2H5, C3H7iso-C3H7n-C4H9iso-C4H9iso-C5H11n-C5H11, and n-C6H13] that have been synthesized and used in biochemical studies as inhibitors of serine hydrolases. These studies suggested the hypothesis that inhibition of serine hydrolases by FAP compoundsoccurs via scission of the P—C bond to organophosphorylate the active site serine. Although P—Cbonds are exceptionally stable in most phosphonates, enzymes such as bacterial carbon-phosphorus lyase are capable of catalyzing their cleavage, thus providing a potential method for destroying toxic phosphonates that might otherwise accumulatein the environment (Adams et al., 2008). Moreover, the structure of diisopentyl-FAP revealed a 1.888 (4) Å P—C bond, which was calculated to be longer and weaker than P—C bonds in phosphonates lacking adjacent –CFgroups.

       Talks presented in most of the following conferences:

CONFERENCE LIST : sample only.

1. Twelfth Annual Quantum Theory Conference, September 10-13, 1979, Oxford, England.
2. American Chemical Society, March 23-28, 1980, Houston, Texas.
3. Second Chemical Congress of the North American Continent, August 24-29, 1980, Las Vegas, Nevada. 
4. South East/South West Regional meeting of the American Chemical Society, December 10-13, 1980, New Orleans . See the rest at
here

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